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Darabi F, Saidijam M, Nouri F, Mahjub R, Soleimani M

A selective substrate for autophagy, p62 (also called sequestosome 1), was reported to competitively interact with the Nrf2-binding site of Keap1, resulting in the indirect activation of Nrf2 (Komatsu et al., 2010)

From a side effect standpoint, the peptides may cause mild water retention or tingling in some users initially, but these effects are typically transient